According to Five Thirty-Eight

Houston has the best chance of all the 6 seeds to win Game 1. Also the best chance to advance to the Sweet 16.

Round of 64 Chance to Win
Houston 72%
Florida 66%
Miami 60%
TCU 57%

Round of 32 Chance to Win
Houston 34%
Florida 32%
Miami 25%
TCU 14%

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And that’s why it’s called MADNESS!!!

https://twitter.com/John_Royal/status/973265696766418944

https://twitter.com/ESPNStatsInfo/status/973607265893863424

https://twitter.com/brauf33/status/973616315532529664